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Heterologous Production of Epothilone C and D in Escherichia coli †

✍ Scribed by Mutka, Sarah C.; Carney, John R.; Liu, Yaoquan; Kennedy, Jonathan

Book ID
126117318
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
385 KB
Volume
45
Category
Article
ISSN
0006-2960

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## Abstract The heterologous production of epothilone D in __Myxococcus xanthus__ was improved by 140‐fold from an initial titer of 0.16 mg/L with the incorporation of an adsorber resin, the identification of a suitable carbon source, and the implementation of a fed‐batch process. To reduce the deg