Heterogeneous systems II: Influence of partitioning and molecular interactions on in vitro biologic activity of preservatives in emulsions

✍ Scribed by Nagin K. Patel; Joyce M. Romanowski

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 657 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600590321

✦ Synopsis

The preservative activity of p-hydroxybenzoic acid esters (parabens) in the presence of a polysorbate Wsorbitan monooleate water system was found to be related to the concentration of the free or unbound paraben. Prediction of required preservative concentration for an emulsified system from a knowledge of oil-water partition coefficients and preservative-macromolecules binding data is illustrated. It was demonstrated by an in Ditro microbiological procedure and using a glass dialysis cell that the fungistatic activity against Aspergdlusniger of methyl-and propylparaben in emulsified systems was primarily a function of the free paraben concentration in the aqueous phase.

Keyphrases 0 p-Hydroxybenzoic acid esters activity-partitioning, molecular interaction, effects 0 Biological activity-emulsion preservatives in uitro 0 Emulsions, effect-preservatives 0 Inhibition determination-dialysis cell * Brij 35, marketed by Atlas Chemical Industries, Inc., Wilmington, * Polyoxyethylene (20) sorbitan monooleate, marketed as Tween SO SDan SO. marketed bv Atlas Chemical Industries. Canada. Ltd..