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Heterogeneity, polyploidy, aneusomy, and 9p deletion in human glioblastoma multiforme

✍ Scribed by Se Hyuck Park; Tatsuhiro Maeda; Gayatry Mohapatra; Frederic M. Waldman; Richard L. Davis; Burt G. Feuerstein

Book ID: 113253542
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 827 KB
Volume: 83
Category: Article
ISSN: 0165-4608
DOI: 10.1016/0165-4608(95)00040-v

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## Abstract The __CDKN2A__ tumor‐suppressor gene in chromosome band 9p21 encoding CDKN2A (also known as p16, INK4A), a negative regulator of cyclin‐dependent kinases, and p14^ARF1^, an activator of __TP53__, is inactivated in many human cancers by point mutations, promoter hypermethylation, or dele