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Genetic Heterogeneity in Human Astrocytomas: Spatial Distribution of P16 and TP53 Deletions in Biopsies

✍ Scribed by Heike Steilen-Gimbel; Wolf-Ingo Steudel; Wolfgang Feiden; Jean-Richard Moringlane; Wolfram Henn; Klaus D Zang

Book ID
114136917
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
219 KB
Volume
113
Category
Article
ISSN
0165-4608

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Alterations of retinoblastoma, p53, p16(
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✍ Toshihide Tsuzuki; Shigeru Tsunoda; Toshisuke Sakaki; Noboru Konishi; Yoshio Hia πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 637 KB

## BACKGROUND. Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, pl6(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G,-S checkpoint.