Heterogeneity of fluorescence in psoriasis after application of 5-aminolaevulinic acid: an immunohistochemical study
β Scribed by M.M. Kleinpenning; T. Smits; E. Ewalds; P.E.J. Van Erp; P.C.M. Van De Kerkhof; M.J.P. Gerritsen
- Book ID
- 108668900
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 669 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0007-0963
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Laser-induced fluorescence (LIF) investigations have been performed in connection with photodynamic therapy (PDT) of basal cell carcinomas and adjacent normal skin following topical application of 5-aminolaevulinic acid (ALA) in order to study the kinetics of the protoporphyrin IX (PpIX) build-up. F
## Abstract Mitochondrial oxygen tension can be measured in vivo by means of oxygenβdependent quenching of delayed fluorescence of protoporphyrin IX (PpIX). Here we demonstrate that delayed fluorescence is readily observed from skin in rat and man after topical application of the PpIX precursor 5βa