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Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

โœ Scribed by Susan M. Kaech; E. John Wherry

Book ID
116570781
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
849 KB
Volume
27
Category
Article
ISSN
1074-7613

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## Abstract To study the role of ILโ€12 as a third signal for Tโ€cell activation and differentiation __in vivo__, direct ILโ€12 signaling to CD8^+^ T cells was analyzed in bacterial and viral infections using the P14 Tโ€cell adoptive transfer model with CD8^+^ T cells that lack the ILโ€12 receptor. Resu