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Heteroduplex screening for molecular defects in factor IX genes from haemophilia B families

โœ Scribed by Shi-Han Chen; Jon M. Schoof; Ann F. Weinmann; Arthur R. Thompson


Book ID
114714050
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
332 KB
Volume
89
Category
Article
ISSN
0007-1048

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The molecular genetics of haemophilia A:
โœ David S. Millar; Barbara Zoll; Uri Martinowitz; Vijay V. Kakkar; David N. Cooper ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 758 KB

A combination of Southern blotting and the analysis of polymerase chain reaction (PCR) amplified DNA fragments was used to screen the factor VIII genes of 527 haemophilia A patients for point mutations within TaqI restriction sites. Since this "directed search" strategy yielded only four gene lesion