Communicated by R. G. H. Cotton Double-stranded heteroduplex molecules that form between a mutant and wild-type D N A strand are often distinguished from homoduplex molecules upon gel electrophoresis. This method, heteroduplex analysis (HA), can be performed rapidly without radioisotopes or speciali
Heteroduplex analysis of the dystrophin gene: Application to point mutation and carrier detection
β Scribed by Prior, Thomas W. ;Papp, Audrey C. ;Snyder, Pamela J. ;Sedra, Mary S. ;Western, Lorraine M. ;Bartolo, Claire ;Moxley, Richard T. ;Mendell, Jerry R.
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 584 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0148-7299
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Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X-linked neuromuscular disorders associated with alterations in the dystrophin gene. Analysis of 45 DMD/BMD patients has identified 18 patients with no deletion in the dystrophin gene. Heteroduplex analysis (HD), single strand
## Communicated by Peter Oefner Beta-thalassemia is a common inherited disease, resulting from one or more of a total of more than 200 different mutations in the b-globin gene (HBB). Efficient and reliable mutation-screening methods are essential in order to establish appropriate prevention program