✦ LIBER ✦

Heterocyclization reaction of 2-(2-methylaziridin-1-yl)-3-ureidopyridines under appel's conditions

✍ Scribed by Ji-Sun Lim; Kee-Jung Lee

Book ID: 102338990
Publisher: Journal of Heterocyclic Chemistry
Year: 2002
Tongue: English
Weight: 61 KB
Volume: 39
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570390518

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✦ Synopsis

Abstract

The reaction of 2‐(2‐methylaziridin‐1‐yl)‐3‐ureidopyridines 12 with triphenylphosphine, carbon tetra‐chloride, and triethylamine (Appel's conditions) led to the corresponding carbodiimides 13, which underwent intramolecular cycloaddition reaction with aziridine under the reaction conditions to give the pyridine‐fused heterocycles, 2,3‐dihydro‐1__H__‐imidazo[2′,3′:2,3]imidazo[4,5‐b]pyridines 16 and 12,13‐dihydro‐5__H__‐1,3 ‐benzodiazepino [2′,3′:2,3] imidazo[4,5‐b]pyridines 17.

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