Heterocyclic tricycles as potential cns agents I: 4-aminoalkylindeno[1,2-c]pyrazoles

✍ Scribed by Thomas L. Lemke; Michael B. Cramer; K. Shanmugam

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 495 KB
• Volume: 67
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600671012

✦ Synopsis

Series of 4-(3-dimethylaminopropyl)-4-hydroxyindeno[1,2-c]pyrazoles and 4-(1-methyl-4-piperidyl)-4-hydroxyindeno[1,2-c-]pyrazoles were synthesized and identified. The compounds were evaluated as potential CNS agents using spontaneous and forced motor activity in mice as an initial test. 2-Ethyl-3-methyl-4-(1-methyl-4-piperidyl)-4-hydroxyindeno[1,2-c]pyrazole possessed significant biological activity.