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Heterocyclic compounds XII. Quinazoline derivatives as potential antifertility agents

✍ Scribed by M. S. Manhas; W. A. Hoffman III; A. K. Bose


Book ID
112125677
Publisher
Journal of Heterocyclic Chemistry
Year
1979
Tongue
English
Weight
263 KB
Volume
16
Category
Article
ISSN
0022-152X

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Benzimidazo[1,2-c]quinazoline dimers as
✍ Miguel F. BraΓ±a; MarΓ­a JesΓΊs PΓ©rez de Vega; Denise Perron; Donna Conlon; Peter F πŸ“‚ Article πŸ“… 1997 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 451 KB πŸ‘ 1 views

## Abstract The 6‐substituted benzimidazo[1,2‐__c__]quinazoline 1 is a lead structure from our DNA intercalator program and is cytotoxic to the human colon cancer tumor line HT‐29 with an inhibitory concentration 50, IC~50~ of 4.00 ΞΌ__M__. In order to try and improve the limited cytotoxicity of thi