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Heterocyclic compounds with a bridgehead nitrogen atom. Synthesis in the imidazo[1,2-c]quinazoline series

โœ Scribed by A. Gueiffier; H. Viols; J. P. Chapat; O. Chavignon; J. C. Teulade; G. Dauphin


Book ID
112129539
Publisher
Journal of Heterocyclic Chemistry
Year
1990
Tongue
English
Weight
439 KB
Volume
27
Category
Article
ISSN
0022-152X

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The n-BuLi and lithium 2,2,6,6-tetramethylpiperidine (LTMP) metalation of imidazo[l,2..alpyrazine heterocycles and subsequent quenching with electrophiles is described. Bromine atoms exhibit different behaviours towards lithiation depending on their positions (3 or 6) on the imidazo[1,2-a]pyrazine h