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Heterocycles through Domino Reactions with Trimethyl Aconitate, a Versatile Synthetic Building Block

✍ Scribed by Daniel Witthaut; Roland Fröhlich; Hans J. Schäfer

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 78 KB
Volume: 40
Category: Article
ISSN: 0044-8249
DOI: 10.1002/1521-3773(20011119)40:22<4212::aid-anie4212>3.0.co;2-n

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✦ Synopsis

The multitalented synthetic reagent trimethyl aconitate (1) is a renewable raw material with a high density of functional groups that up to now has only been scarcely used as a C building block. Domino reactions with 1 consisting of imine additions and intramolecular acylations provide simple access to heteropolycycles in one-pot reactions. For example, 1 reacts with N-methylbenzylidenamine (2) to give the spiro[pyrrolidinone-3,3'-dihydropyrrolinone] 3 in 40 % yield.

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ChemInform Abstract: Heterocycles Throug

ChemInform Abstract: Heterocycles Through Domino Reactions with Trimethyl Aconitate, a Versatile Synthetic Building Block.

✍ Daniel Witthaut; Roland Froehlich; Hans J. Schaefer 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB

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