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Hetero-Diels–Alder synthesis of the spiroketal fragment of reveromycin A

✍ Scribed by Mariana El Sous; Mark A Rizzacasa

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
132 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The asymmetric synthesis of the 6,6-spiroketal fragment 15 of the epidermal growth factor inhibitor reveromycin A (1) is described. A hetero-Diels-Alder reaction was utilized to construct the 6,6-spiroketal 14 and subsequent stereoselective hydroboration provided reveromycin A spiroketal 15.

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