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Hesseltins B–G, novel meroterpenoids from a new Penicillium species

✍ Scribed by Richard K. Phipps; Charlotte H. Gotfredsen; Søren R. Paludan; Jens C. Frisvad; Kathrine Eriksen; Bent O. Petersen; Jens Ø. Duus; Thomas O. Larsen

Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
297 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis

Six new meroterpenoid compounds, hesseltins B-G, were isolated from Penicillium species along with the previously described hesseltin A. A further 14 compounds, which turned out to be photoisomers, were detected during purification and were subsequently isolated. The structures of these analogues were elucidated by comparison of their NMR spectral data with that of hesseltin A. None of the new hesseltins showed antiviral activity in a Herpes simplex virus type 2 assay.

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