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Heritable fragile sites on human chromosomes

✍ Scribed by G. R. Sutherland

Publisher
Springer
Year
1979
Tongue
English
Weight
312 KB
Volume
53
Category
Article
ISSN
0340-6717

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✦ Synopsis

The fragile site at Xq27 which is associated with X-linked retardation with macroorchidism has been studied in 21 retarded males. These males were from 12 families, and studies of nine of the familes were possible. Detection of carrier females is difficult, especially with increasing age. The fragile site was demonstrated in only five of 13 obligate carrier females. It is concluded that using present methods, cytogenetic detection of carriers is fairly reliable in females aged less than 20--25 years but unreliable in older females.

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