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Hereditary optic neuropathies share a common mitochondrial coupling defect

✍ Scribed by Arnaud Chevrollier; Virginie Guillet; Dominique Loiseau; Naïg Gueguen; Marie-Anne Pou de Crescenzo; Christophe Verny; Marc Ferre; Hélène Dollfus; Sylvie Odent; Dan Milea; Cyril Goizet; Patrizia Amati-Bonneau; Vincent Procaccio; Dominique Bonneau; Pascal Reynier


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
205 KB
Volume
63
Category
Article
ISSN
0364-5134

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Leber hereditary optic neuropathy: Does
✍ Chinnery, Patrick F. ;Andrews, Richard M. ;Turnbull, Douglass M. ;Howell, Neil 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB 👁 2 views

Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch