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HER2/neu expression and amplification in non-small cell lung cancer prior to and after neoadjuvant therapy

✍ Scribed by Junker, Klaus; Stachetzki, Ulf; Rademacher, Daniela; Linder, Albert; Macha, Hans-Nicol; Heinecke, Achim; Müller, Klaus-Michael; Thomas, Michael

Book ID
119319101
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
324 KB
Volume
48
Category
Article
ISSN
0169-5002

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HER2 is an erbB/HER type 1 tyrosine kinase receptor that is frequently over-expressed in malignant epithelial tumours. Herceptin, a humanised mouse monoclonal antibody to HER2, is proven therapeutically in the management of metastatic breast cancer, significantly prolonging survival when combined wi