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HER2 overexpression and activation, and tamoxifen efficacy in receptor-positive early breast cancer

✍ Scribed by Christian F. Singer; Daphne Gschwantler-Kaulich; Anneliese Fink-Retter; Georg Pfeiler; Ingrid Walter; Gernot Hudelist; Samir Helmy; Anne-Catherine Spiess; Wolfgang Lamm; Ernst Kubista

Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
362 KB
Volume
135
Category
Article
ISSN
1432-1335

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## Abstract Although tamoxifen (TAM) is used for the front‐line treatment and prevention of estrogen receptor‐positive (ER+) breast tumors, nearly 40% of estrogen‐dependent breast tumors do not respond to TAM treatment. Moreover, the positive response is usually of short duration, and most tumors e