HER2 status in hormone receptor positive premenopausal primary breast cancer adds prognostic, but not tamoxifen treatment predictive, information

p27Kip1 is a predictive factor for tamox

p27Kip1 is a predictive factor for tamoxifen treatment response but not a prognostic marker in premenopausal breast cancer patients

✍ Maria Stendahl; Sofie Nilsson; Caroline Wigerup; Karin Jirström; Per Ebbe Jönsso 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 489 KB

## Abstract The cell‐cycle regulating protein p27^Kip1^ (p27) has dual roles by acting as both a cdk inhibitor and as an assembly factor for different cdk complexes. Loss of p27 has been linked to malignant features in tumours; however, the exact role of p27 deregulation in breast cancer regarding