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HER2 Amplification Ratios by Fluorescence In Situ Hybridization and Correlation with Immunohistochemistry in a Cohort of 6556 Breast Cancer Tissues

✍ Scribed by Marilyn A. Owens; Bruce C. Horten; Moacyr M. Da Silva

Book ID: 115075628
Publisher: CIG Media Group, LP.
Year: 2004
Tongue: English
Weight: 161 KB
Volume: 5
Category: Article
ISSN: 1526-8209
DOI: 10.3816/cbc.2004.n.011

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Fluorescence in situ hybridization (FISH) is a validated method for detection of HER-2/neu gene amplification and was recently approved by the FDA for diagnostic use in paraffin-embedded tissue. Its use in cytologic specimens, however, has not been investigated. To see whether HER-2/neu gene amplifi