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HER-2/neu gene copy quantified by real-time PCR and serum HER-2/neu by Elisa assay: comparison with fluorescence in situ hybridization and immunohistochemistry

✍ Scribed by C Tse; D Brault; J Gligorov; M Antoine; K Lelay; J.P Lotz

Book ID: 118622346
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 175 KB
Volume: 2
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(04)90998-6

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Fluorescence in situ hybridization (FISH) is a validated method for detection of HER-2/neu gene amplification and was recently approved by the FDA for diagnostic use in paraffin-embedded tissue. Its use in cytologic specimens, however, has not been investigated. To see whether HER-2/neu gene amplifi