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Heptakis(6-amino-6-deoxy)-β-cyclodextrin as a chiral selector for the separation of anionic analyte enantiomers by capillary electrophoresis

✍ Scribed by Natalia Budanova; Elena Shapovalova; Sergei Lopatin; Valery Varlamov; Oleg Shpigun

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
108 KB
Volume
25
Category
Article
ISSN
0173-0835

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✦ Synopsis

Abstract

A hepta‐substituted β‐cyclodextrin bearing seven amino groups, heptakis(6‐amino‐6‐deoxy)‐β‐cyclodextrin (per‐6‐NH~2~‐β‐CD) was successfully used as a chiral selector for the enantioseparation of different anionic analytes. The running buffer pH and chiral selector concentration were the studied parameters crucial in achieving the maximum possible enantioresolution. Enantiomeric separation of a mixture of seven carboxybenzyl‐amino acids was achieved in 24 min. Excellent resolution was obtained for carboxybenzyl‐tryptophan (R~s~ = 11.2).

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