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Hepatocyte growth factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25+Foxp3+ regulatory T cells

✍ Scribed by Benkhoucha, M.; Santiago-Raber, M.-L.; Schneiter, G.; Chofflon, M.; Funakoshi, H.; Nakamura, T.; Lalive, P. H.


Book ID
118126398
Publisher
National Academy of Sciences
Year
2010
Tongue
English
Weight
999 KB
Volume
107
Category
Article
ISSN
0027-8424

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Tolerogenic dendritic cells induced by v
✍ Luciano Adorini; Giuseppe Penna; Nadia Giarratana; Milan Uskokovic πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 116 KB

## Abstract Dendritic cells (DCs) not only induce but also modulate T cell activation. 1,25‐dihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] induces DCs with a tolerogenic phenotype, characterized by decreased expression of CD40, CD80, and CD86 costimulatory molecules, low IL‐12 and enhanced IL‐10 secretion