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Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy

✍ Scribed by A. Floreani; I. Carderi; D. Paternoster; G. Soardo; F. Azzaroli; W. Esposito; M. Montagnani; D. Marchesoni; A. Variola; E. Rosa Rizzotto; C. Braghin; G. Mazzella


Book ID
119228842
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
97 KB
Volume
40
Category
Article
ISSN
1590-8658

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Intrahepatic cholestasis of pregnancy (ICP) is defined as pruritus and elevated bile acid serum concentrations in late pregnancy. Splicing mutations have been described in the multidrug resistance p-glycoprotein 3 (MDR3, ABCB4) gene in up to 20% of ICP women. Pedigrees studied were not large enough