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[302] MDR3 MUTATIONS IN A LARGE COHORT OF ITALIAN WOMEN WITH INTRAHEPATIC CHOLESTASIS OF PREGNANCY (ICP)

✍ Scribed by I. Carderi; D. Paternoster; G. Soardo; F. Azzaroli; G. Mazzella; W. Esposito; M. Montagnani; D. Marchesoni; A. Variola; E. Rosa Rizzotto; A. Floreani


Book ID
118567114
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
146 KB
Volume
46
Category
Article
ISSN
0168-8278

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Intrahepatic cholestasis of pregnancy (ICP) is defined as pruritus and elevated bile acid serum concentrations in late pregnancy. Splicing mutations have been described in the multidrug resistance p-glycoprotein 3 (MDR3, ABCB4) gene in up to 20% of ICP women. Pedigrees studied were not large enough