Hepatitis C virus E2 links soluble human CD81 and SR-B1 protein
✍ Scribed by Tae-Hwe Heo; Song-Mi Lee; Birke Bartosch; François-Loïc Cosset; Chang-Yuil Kang
- Book ID
- 116967767
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 290 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0168-1702
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## Abstract Binding of the hepatitis C virus (HCV) envelope protein E2 to CD81 provides a costimulatory signal for human T cells. This phenomenon may play a role in liver damage and autoimmune manifestations associated with HCV infection. Here we show that cross‐linking of CD81 by HCV E2 induced a
## Abstract The question was asked whether a predicted envelope protein, considered to be processed from the polyprotein precursor encoded by the putative E2/NS1 region of the hepatitis C virus (HCV) genome, may be observed in HCV‐infected humans. Two polyclonal antibodies against recombinant E2/NS