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Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3

✍ Scribed by Takumi Kawaguchi; Takafumi Yoshida; Masaru Harada; Takao Hisamoto; Yumiko Nagao; Tatsuya Ide; Eitaro Taniguchi; Hiroto Kumemura; Shinichiro Hanada; Michiko Maeyama; Shinji Baba; Hironori Koga; Ryukichi Kumashiro; Takato Ueno; Hisanobu Ogata; Akihiko Yoshimura; Michio Sata


Book ID
117021639
Publisher
American Society for Investigative Pathology
Year
2004
Tongue
English
Weight
355 KB
Volume
165
Category
Article
ISSN
0002-9440

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The hepatitis C virus core protein of ge
✍ Valerio Pazienza; Sophie ClΓ©ment; Paolo Pugnale; StΓ©phanie Conzelman; Michelange πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 602 KB

Both molecular and clinical evidence support a link between HCV infection and insulin resistance. We examined the in vitro interaction between the HCV core protein of genotypes 3a and 1b with the insulin-signaling pathway. We measured the expression levels of insulin receptor substrate 1 (IRS-1), IR