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[436] THE HEPATITIS C VIRUS CORE PROTEIN OF GENOTYPES 3a AND 1b DOWN-REGULATES INSULIN RECEPTOR SUBSTRATE 1 VIA GENOTYPE-SPECIFIC MECHANISMS

✍ Scribed by V. Pazienza; S. Clement; P. Pugnale; S. Conzelman; M. Foti; A. Mangia; F. Negro


Book ID
117375531
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
150 KB
Volume
46
Category
Article
ISSN
0168-8278

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Both molecular and clinical evidence support a link between HCV infection and insulin resistance. We examined the in vitro interaction between the HCV core protein of genotypes 3a and 1b with the insulin-signaling pathway. We measured the expression levels of insulin receptor substrate 1 (IRS-1), IR