Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2
✍ Scribed by A. J. Pérez-Berná; A. S. Veiga; M. A. R. B. Castanho; J. Villalaín
- Book ID
- 108886101
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 557 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1352-0504
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## Abstract The binding sites for human antibodies recognising antigenic domains within the hepatitis C virus (HCV) core protein were analyzed using synthetic peptides. Omission peptide analogues where a pair of residues was sequentially omitted were produced corresponding to the regions 1–18, 11–2
Interferons (IFNs) and the interferon-stimulated genes (ISGs) play a central role in antiviral responses against hepatitis C virus (HCV) infection. We have reported previously that ISGs, including guanylate binding protein 1 (GBP-1), interferon alpha inducible protein (IFI)-6-16, and IFI-27, inhibit