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Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the ‘a’ epitope of the surface antigen are sensitive to ganciclovir

✍ Scribed by Chong Jin Oon; Wei Ning Chen; Nichole Lim; Shiuan Koh; Gek Keow Lim; Ai Lin Leong; Gek San Tan

Book ID: 114145207
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 137 KB
Volume: 41
Category: Article
ISSN: 0166-3542
DOI: 10.1016/s0166-3542(99)00007-8

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Lamivudine is effective in suppressing replication of hepatitis B virus (HBV). However, the emergence of HBV variants resistant to lamivudine is a concern. Lamivudine resistance has been attributed mainly to a substitution of isoleucine or valine for methionine at residue 550 (M550I or M550V) in the