Precore defective HBV mutants may gradually prevail because of immune selection and explain spontaneous seroconversion from HBeAg to anti-HBe in HBV carriers. We have analyzed whether the presence of precore HBV mutants is a determinant of responsiveness to interferon-a therapy. Fifteen carriers (ni
Hepatitis B virus precore mutants in HBeAg carriers with chronic hepatitis treated with interferon
✍ Scribed by P. Lampertico; A. Manzin; M. G. Rumi; S. Paolucci; E. Del Ninno; M. Dementi; M. Colombo
- Book ID
- 119836560
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 551 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1352-0504
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## BACKGROUND. A point mutation from G to A at nucleotide (nt) 1896 of the precore region of hepatitis B virus (HBV) DNA has been shown to be associated with fulminant and severe hepatitis. Further studies have suggested that this point mutation, together with additional mutations in the precore p