Hepatitis B virus genotypes and precore mutations in Scottish blood donors
β Scribed by F. Davidson; C. Lycett; E. Sablon; J. Petrik; B. C. Dow
- Book ID
- 110912630
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 99 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0042-9007
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## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in
The precore-core gene of hepatitis B virus (HBV) was directly sequenced from serum samples of 42 patients with chronic B hepatitis (19 hepatitis B e antigen [HBeAg]+ and 23 anti-me+). Viral genotypes were determined by comparison with ll reference sequences and by restriction analysis. Genotype A wa