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Frequency and distribution of hepatitis B virus genotypes among eastern Indian voluntary blood donors: Association with precore and basal core promoter mutations

โœ Scribed by Avik Biswas; Partha K Chandra; Sibnarayan Datta; Rajesh Panigrahi; Arup Banerjee; Shekhar Chakrabarti; Kalidas Biswas; Dipak Patra; Prasun Bhattacharya; Kuntal Biswas; Runu Chakravarty

Book ID
118088026
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
187 KB
Volume
39
Category
Article
ISSN
1386-6346

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## Abstract Mutations in the basal core promoter (BCP) and precore (PC) regions are associated with persistent and intermittently high hepatitis B virus (HBV) replication in several patients. The variability in the functional domains of BCP and PC region of HBV and their association with disease pr

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Basal core promoter, precore region mutations of HBV and their association with e antigen, genotype, and severity of liver disease in patients with chronic hepatitis B in India
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Spontaneous mutations of hepatitis B virus (HBV) could influence the severity of liver disease. Since the basal core promoter (BCP) and the precore (Pc) regions are important for viral replication, these regions were examined for naturally occurring mutations and were correlated with the genotype, e