Hepatic Vitamin K-Dependent Carboxylation of Blood-Clotting Proteins
โ Scribed by Howard A. Liebman; Barbara C. Furie; Bruce Furie
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 906 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The __Drosophila__ ฮณโglutamyl carboxylase (dฮณC) has substrate recognition properties similar to that of the vertebrate ฮณโcarboxylase (ฮณC), and its carboxylated product yield, in vitro, was shown to be more than that obtained with the human enzyme. However, whether the __Drosophila__ enz
There are seven known vitamin K-dependent proteins in blood. These proteins require calcium ion for expressing their full biological activities. Calcium ion also induces conformational changes in this class of proteins. Taking advantage of the ligand induced conformational changes, a number of uniqu
## Abstract The present study characterizes the anticoagulant resistance mechanism in a Danish bromadioloneโresistant strain of Norway rats (__Rattus norvegicus__), with a Y139C VKORC1 mutation. We compared liver expression of the VKORC1 gene, which encodes a protein of the vitamin K 2,3โepoxide re
We report the first direct method for the identification of the vitamin K-dependent Ca2+ binding amino acid, gamma-carboxyglutamic acid (Gla), in the sequencing of proteins. The carboxyl groups on the protein are first converted to methyl esters with methanolic HCl, a procedure that reduces the pola