Responses of renal and hepatic vitamin k dependent γ-glutamyl carboxylase substrates to warfarin and vitamin k treatments

Characterization of bromadiolone resista

Characterization of bromadiolone resistance in a danish strain of Norway rats, rattus norvegicus, by hepatic gene expression profiling of genes involved in vitamin k-dependent γ-carboxylation

✍ Mette Drude Markussen; Ann-Charlotte Heiberg; Merete Fredholm; Michael Kristense 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB

## Abstract The present study characterizes the anticoagulant resistance mechanism in a Danish bromadiolone‐resistant strain of Norway rats (__Rattus norvegicus__), with a Y139C VKORC1 mutation. We compared liver expression of the VKORC1 gene, which encodes a protein of the vitamin K 2,3‐epoxide re