Hepatic drug metabolism in the elderly
β Scribed by Kenichi Kitani
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 549 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0270-9139
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Certain drugs with metabolism that obeys Michaelis-Menten kinetics are extensively bound in the liver. During the initial distribution phase after a single dose, the binding sites act as a "sink' and compete with the metabolizing enzymes for the drug. After this phase is completed, the bound sites a
The effects of chronic ethanol consumption and variations in dietary protein content on micro-soma1 drug metabolism were studied in rats pair-fed liquid diets containing 10, 20, or 30% dietary protein with or without ethanol. In uiuo drug metabolism was measured by aminopyrine breath tests and amino