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Hepatic abscess as the single manifestation of X-linked chronic granulomatous disease

✍ Scribed by Annamária Székely; Mózes Péter Jr.; Melinda Erdős; László Maródi


Book ID
112167966
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
70 KB
Volume
58
Category
Article
ISSN
1545-5009

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The most frequent form of chronic granulomatous disease (CGD) is caused by inactivation of the CYBB gene, which encodes the gp91-phox subunit of phagocyte NADPH oxidase. This defect prevents phagocytes from producing reactive oxygen species and thus from eradicating bacterial and fungal infections.