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Heparin specifically inhibits binding of apolipoprotein E to amyloid β-peptide

✍ Scribed by Vladimir V Shuvaev; Gérard Siest


Book ID
117470438
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
143 KB
Volume
280
Category
Article
ISSN
0304-3940

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Apolipoprotein E (apoE) is believed to be closely involved in the pathogenesis of Alzheimer's disease (AD) because of its ability to bind to ␤-amyloid (A␤), the primary component of senile plaques. The presence of cystein residues in apoE2 and apoE3 allows these isoforms to form disulfide-linked com