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Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid

✍ Scribed by T. Wisniewski; A. Golabek; E. Matsubara; J. Ghiso; B. Frangione


Book ID
115572808
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
400 KB
Volume
192
Category
Article
ISSN
0006-291X

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✍ Kazuyoshi Yamauchi; Minoru Tozuka; Tetsuo Nakabayashi; Mitsutoshi Sugano; Hiroya 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB

Apolipoprotein E (apoE) is believed to be closely involved in the pathogenesis of Alzheimer's disease (AD) because of its ability to bind to ␤-amyloid (A␤), the primary component of senile plaques. The presence of cystein residues in apoE2 and apoE3 allows these isoforms to form disulfide-linked com