Heparin releases heparan sulfate from the cell surface
β Scribed by Paul M. Kraemer
- Book ID
- 118311960
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 385 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0006-291X
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Heparin stimulates 2-3-fold, in a concentration-dependent manner, the synthesis of heparan sulfate secreted by cultured endothelial cells. The increase in synthetic rate takes place immediately after exposure of the cells to heparin, affects only heparan sulfate, and i s specific for the endothelial
## Abstract Heparan sulfate (HS) proteoglycans are essential components of the cellβsurface and extracellular matrix (ECM) which provide structural integrity and act as storage depots for growth factors and chemokines, through their HS side chains. Heparanase (HPSE) is the only mammalian endoglycos
Evidence suggests that endothelial cell layer heparan sulfate proteoglycans include a variety of different sized molecules which most likely contain different protein cores. In the present report, approximately half of endothelial cell surface associated heparan sulfate proteoglycan is shown to be r