Heparin and coumadin versus acetylsalicylic acid for prevention of restenosis after coronary angioplasty

✍ Scribed by Ali Reza Garachemani; Martin Fleisch; Stephan Windecker; Dorothy Pfiffner; Bernhard Meier

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 246 KB
• Volume: 55
• Category: Article
• ISSN: 1522-1946
• DOI: 10.1002/ccd.10084

✦ Synopsis

Abstract

The purpose of the present study was to determine whether postprocedural antithrombotic therapy with prolonged heparin infusion followed by 6 months of oral anticoagulation in addition to acetylsalicylic acid (ASA) reduces the incidence of angiographic restenosis after successful PTCA. One hundred ninety‐one patients with uncomplicated PTCA were randomized into two groups: one group was discharged with ASA 100 mg only (G1) and the other group was additionally treated with 12–24 hr of heparin infusion and overlapping oral anticoagulation with coumadin for 6 months (G2). The two groups were comparable with respect to age, gender, coronary risk profile, clinical presentation, and angiographic lesion characteristics. Stents were implanted in 33% and 36% of the G1 and G2 patients, respectively. In‐hospital myocardial infarction occurred in 4% of the G1 and 3% of the G2 patients. One patient in G1 died of subacute stent thrombosis (day 3). Six‐month angiographic follow‐up was obtained in 90% of G1 patients and 94% of G2 patients. Restenosis occurred in 30% and 33% of the patients and mean diameter stenoses at follow‐up were 40% ± 28% and 39% ± 24%, respectively. Thrombin inhibition with heparin infusion followed by 6 months of oral anticoagulation did not reduce angiographic restenosis among patients undergoing PTCA with or without stent implantation. The occurrence of acute ischemic complications was also comparable in the two groups. Cathet Cardiovasc Intervent 2002;55:315–320. © 2002 Wiley‐Liss, Inc.