A first trial in the clinical application of photodynamic therapy for the prevention of restenosis after coronary-stent placement

✍ Scribed by Mikio Usui; Manabu Miyagi; Shinya Fukasawa; Takeshi Hara; Naoya Ueyama; Hitoshi Nakajima; Ryu Takata; Atsuko Sasame; Ken Tamura; Yuuichi Naitou; Akira Yamashina

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 153 KB
• Volume: 34
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.20018

✦ Synopsis

Abstract

Background and Objectives

The aim of this clinical study was to evaluate the safety of local delivery of a photosensitizer followed by photodynamic therapy (PDT), to determine its effectiveness in reducing in‐stent restenosis.

Study Design/Patients and Methods

Porfimer sodium was administered via a local delivery catheter to five coronary‐stent implanted lesions followed by irradiation with a pulse laser. Coronary angiography (CAG) was performed at the baseline, after the procedure and at a 6‐month follow‐up.

Results

By the 18‐month clinical follow‐up, no adverse events such as photodermatosis, or myocardial ischemia had occurred. At the follow‐up, no coronary embolization, dissection, or aneurysmal dilatation was observed in the CAG. In‐stent diameter stenosis, late loss, and loss index were 19.16±8.20%, 0.37±0.18 mm, and 0.19±0.12, respectively. No in‐stent restenosis was observed.

Conclusions

This study suggests that PDT, with local delivery of Porfimer sodium, is safe and may be a feasible technique in preventing in‐stent restenosis. Lasers Surg. Med. 34:235–241, 2004. © 2004 Wiley‐Liss, Inc.