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Heparanase activation induces epidermal hyperplasia, angiogenesis, lymphangiogenesis and wrinkles

✍ Scribed by Shunsuke Iriyama; Yukiko Matsunaga; Satoshi Amano

Book ID
111244628
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
612 KB
Volume
19
Category
Article
ISSN
0906-6705

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## Abstract Heparanase, a heparan sulfate‐specific endo‐β‐D‐glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans (ECM HSPG). Heparanase activity correlates with the metastatic propensity of tumor cells. Suramin