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Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors

✍ Scribed by Murayama, K; Kimura, T; Tarutani, M; Tomooka, M; Hayashi, R; Okabe, M; Nishida, K; Itami, S; Katayama, I; Nakano, T

Book ID
110072271
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
278 KB
Volume
26
Category
Article
ISSN
0950-9232

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## Abstract We found that caffeine significantly inhibited epidermal growth factor (EGF)‐ and 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter‐induced cell transformation was also blocked by treatment with an adenosi