✦ LIBER ✦

Hemosiderosis with diabetes mellitus in untransfused hemoglobin H disease

✍ Scribed by Chim, C.S.; Chan, Vivian; Todd, D.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 155 KB
Volume: 57
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199802)57:2<160::aid-ajh12>3.0.co;2-g

No coin nor oath required. For personal study only.

✦ Synopsis

A 37-year-old untransfused, non-drinking man with Hemoglobin H-CS disease presented with insulin-dependent diabetes mellitus, markedly elevated serum ferritin level, and marked iron deposition in hepatocytes. He did not carry either of the two common mutations of the HLA-H gene for hereditary hemochromatosis, namely, Cys282Tyr and His68Asp, nor did he have the associated HLA marker (HLA-A3, B7 nor B-14) for the disease. Patient with HbH disease should be monitored for iron overload. Am.

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