Hemoglobin: Insights into protein structure, function, and evolution

✍ Scribed by Jay F. Storz

• Publisher: Oxford University Press
• Year: 2018
• Tongue: English
• Leaves: 255
• Edition: 1
• Category: Library

✦ Synopsis

The primary aim of this book is to provide a synthesis of our current understanding of hemoglobin function and evolution, and to illustrate how research on one particular family of proteins has provided general insights into mechanisms of protein evolution and biochemical adaptation. In doing so, it will also promote an appreciation of how mechanistic insights into protein function can enrich our understanding of how evolution works. Reciprocally, it highlights how approaches in evolutionary genetics (such as phylogenetic comparative methods and ancestral sequence reconstruction) can be brought to bear on questions about the functional evolution of proteins. This treatise on the functional evolution of hemoglobin illustrates how research on a single, well-chosen model system can enhance our investigative acuity and bring key conceptual questions into especially sharp focus.

✦ Table of Contents

Title
Copyright
Preface
1 – Principles of Protein Structure
2 – A Study in Scarlet
3 – Allosteric Theory
4 – Hemoglobin Structure and Allosteric Mechanism
5 – Evolution of the Vertebrate Globin Gene Family
6 – Gene Duplication and Hemoglobin Isoform Differentiation
7 – The Evolution of Novel Hemoglobin Functions and Physiological Innovations
8 – Biochemical Adaptations to Envirnmental Hypoxia
9 – Darwin's Molecule
Index
Plates

✦ Subjects

adaptation, biochemical adaptation, gene duplication, globin, hemoglobin, hypoxia, oxygen transport, red blood cell, molecular evolution, protein evolution