𝔖 Bobbio Scriptorium
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Hemodynamic effects of a series of new trypanocidal indoleamidino compounds

✍ Scribed by U. Steinmann; Prof. Dr. C.-J. Estler; O. Dann

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
457 KB
Volume
7
Category
Article
ISSN
0272-4391

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✦ Synopsis

The influence of 17 recently developed trypanocidal amidino compounds on blood pressure, heart rate, and carotid blood flow has been investigated in rats. Their cardiovascular effects were compared with those produced by pentamidine (Lomidine@) and diminazen (Berenil@). All compounds lowered the arterial blood pressure, especially the diastolic pressure, and almost all agents caused a reflex tachycardia and some reduction of the carotid blood flow. The hypotensive potency of the compounds can be reduced by alterations of the chain length between the cation moieties.

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