The effect of calcium channel blocking agents on the reductive metabolism of halothane in liver microsomes of guinea pigs was investigated. The reaction mixture for the measurement of the end products consisted of microsomal suspension, 5 mM NADPH, calcium channel blocking agents (verapamil, diltiaz
Hemodynamic and metabolic effects of the calcium channel blocking agent nitrendipine
β Scribed by Johnson, Brian F; Romero, Luis; Marwaha, Raj
- Book ID
- 109844046
- Publisher
- Nature Publishing Group
- Year
- 1986
- Tongue
- English
- Weight
- 416 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0009-9236
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π SIMILAR VOLUMES
The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males. Isradipine did not produce a significant change in systolic or diastolic blood pressure, and glomerular filtration rate,
Wc cxamincd the ability of nitrendipine, a calcium antagonist believed to block the voltage-sensitive calcium channcls in a number of excitable membranes, to affect the calcium spike duration and rate of rise (DviDt) in 4-week-old cultured mouse dorsal root ganglion neurons. Concentrations of 10 nM-