Renal effects of the new calcium channel blocking drug isradipine

✍ Scribed by B. K. Krämer; M. Häussler; K. M. Ress; G. A. Müller; K. J. Burger; T. Risler

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 361 KB
• Volume: 39
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00315405

✦ Synopsis

The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males. Isradipine did not produce a significant change in systolic or diastolic blood pressure, and glomerular filtration rate, renal plasma flow, renal vascular resistance, and urinary albumin excretion remained constant. There was a marked natriuretic and diuretic effect about 1-3 h after isradipine. Plasma renin activity showed a slight, insignificant increase 1 h after dosing. Uric acid clearance and beta 2-microglobulin excretion showed no significant changes, despite an increase in sodium clearance, suggesting an additional mechanism of action other than the proximal tubular natriuretic effect of isradipine in normotensive volunteers.